Unfashionable Premier League side Fulham knocked favourites Juventus out of the Europa League after an astonishing 4-1 win over the Italians who finished the last 16 second leg game with nine men on Thursday.
Chelsea's stuttering form continued on Saturday when the Premier League leaders kicked off a hectic holiday programme with a 0-0 draw at Birmingham City.
Manchester United stayed put atop the English Premier League after 2-0 victory over Reading as Arsenal routed Fulham 3-0 and Chelsea beat Birmingham City 1-0.
Paul Scholes and Wayne Rooney were sent of as champions Manchester United were beaten while Chelsea lost to Tottenham Hotspur in teh English Premier League.
Everton lost ground in the race for a Champions League place on Sunday when they went down 1-0 to struggling Fulham at Craven Cottage, a ground where the Merseysiders have not mustered a point in 42 years. In the day's other games Manchester City came from behind to beat Tottenham Hotspur 2-1 while Wigan Athletic beat Bolton Wanderers 1-0 despite playing with 10 men for 85 minutes.
Tottenham Hotspur to a 4-0 win at Fulham while Manchester City beat Preston 3-1 to reach the FA Cup quarter-finals.
Holders Chelsea advanced to the semi-finals of the FA Cup with a 2-0 home win over Stoke City while Aston Villa joined them after coming from 2-0 down to win 4-2 at Reading with a John Carew hat-trick on Sunday.
Chelsea booked their place in the League Cup semi-finals with a late 2-1 win at Fulham.
IMAGES from the English Premier League matches played on Saturday.
Liverpool moved one win away from sealing the Premier League title as substitute Trent Alexander-Arnold secured a 1-0 victory at Leicester City
Goals from Steve Sidwell and Dimitar Berbatov helped Fulham end a six-match losing streak with a 2-0 victory over Aston Villa on Sunday.
IMAGES from the Premier League matches played on Sunday.
Italy and Nigeria played out a thrilling 2-2 draw which included a goal-of-the-season contender from Shola Ameobi in an entertaining friendly at Fulham's Craven Cottage on Monday.
IMAGES from the English Premier League matches played on Saturday.
A preview of the line-up action in the English Premier League
Vitaliy Mykolenko's 39th-minute own goal had put Luton ahead before Jack Harrison cheered the Everton faithful with an equaliser in the 55th minute, hammering in a low shot that Luton keeper Tim Krul allowed to let slip through his hands.
Chelsea beat Fulham 3-1 to open a four-point lead at the top of the Premier League on Saturday while Newcastle United's 4-1 win was marred by manager Alan Pardew's dismissal for head-butting Hull City's David Meyler.
United States forward Clint Dempsey is rejoining Fulham on loan for two months from Major League Soccer's Seattle Sounders, the struggling Premier League club said on its website on Tuesday.
Manchester City roared back to the top of the Premier League with a 6-1 thrashing of Bournemouth after Manchester United steadied the ship
Arsenal were held to a 1-1 Premier League draw by London rivals Fulham on a grey wet Sunday at Craven Cottage as Raul Jimenez scored early for the hosts and William Saliba equalised for the visitors at the start of the second half.
Fulham defender Sascha Riether has been charged by the FA with violent conduct for a challenge on Manchester United's Adnan Januzaj which was not seen by the match officials after the incident was dealt with under a new scheme.
Images from Saturday's matches in the Premier League.
IMAGES from the Premier League matches played on Saturday.
IMAGES from the English Premier League matches played on Sunday
Tottenham Hotspur's Son Heung-min returned to form with two goals in his side's 3-0 defeat of second-tier Preston North End in the FA Cup fourth round and Casemiro also grabbed a brace in Manchester United's 3-1 win over Reading.
Images from the English Premier League matches played on Sunday night.
Stoke City manager Mark Hughes has admitted that he made a mistake when he resigned as Fulham boss in 2011.
Harry Kane's hat-trick turned Tottenham Hotspur's potentially tricky FA Cup fifth-round tie at Championship side Fulham into a Sunday stroll by the River Thames as they won 3-0 at Craven Cottage.
A summary of Tuesday's action in the Premier League.
Oldham Athletic and Barnet provided some old-fashioned FA Cup magic with shock victories against much more illustrious opponents but English champions Manchester City proved ruthless as they scored seven times in the third round on Sunday.
Reigning champions Manchester City took the lead after 24 seconds but suffered a shock 2-1 defeat at Newcastle United.
Everton won 1-0 at bottom club Sunderland to leapfrog Arsenal into fourth place in the Premier League on Saturday and the battle at the other end of the table intensified with wins for three clubs in danger of relegation.
Fulham forgot their Premier League struggles to sweep into the FA Cup fourth round with a 3-0 victory over fellow top-flight strugglers NorwichCity in a third-round replay on Tuesday.
Images from Sunday's action in the Premier League.
IMAGES from the Premier League matches played on Saturday
Athletic Bilbao beat Barcelona 4-2 at home to knock them out of the Copa del Rey
The defeat halted Brighton's impressive three-game winning streak which included a 4-1 win over Chelsea and a 3-1 victory at Arsenal in the League Cup on Wednesday.
Images from the English Premier League matches played on Saturday
Kevin de Bruyne struck twice to inspire Manchester City to a dominant 4-2 win at Crystal Palace on Saturday and move the champions level on points with Liverpool at the top of the Premier League table.
Martin Jol's two-year spell as Fulham manager ended on Sunday after the Dutchman proved unable to reverse the club's sinking fortunes.